I. Introduction to Game Theory in Cancer
نویسنده
چکیده
acidity and k the cost of a glycolytic metabolism. The proportion of invasive cells increase as we increase the cost of living in an acid environment and decrease the cost of glycolysis, factors that should ease the emergent of glycolytic cells. Abstract— Cancers arise from genetic abberations but also consistently display high levels of intra-tumor heterogeneity and evolve according to Darwinian dynamics. This makes evolutionary game theory an ideal tool in which to mathematically capture these cell-cell interactions and in which to investigate how they impact evolutionary dynamics. In this chapter we present some examples of how evolutionary game theory can elucidate cancer evolution.
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